Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model . Request PDF on ResearchGate | Antibiotic penetration and bacterial killing in a Pseudomonas aeruginosa biofilm model | Treating biofilm infections successfully is a challenge. We hypothesized that biofilms may be considered as independent compartments with particular pharmacokinetics. We therefore studied the pharmacokinetics and pharmacodynamics of tobramycin in a seaweed alginate-embedded... www.researchgate.net